Cholinergic mechanisms and REM sleep abnormalities in schizophrenia
نویسندگان
چکیده
منابع مشابه
Cholinergic modulation of GABAergic and glutamatergic transmission in the dorsal subcoeruleus: mechanisms for REM sleep control.
STUDY OBJECTIVES Dorsal subcoeruleus (SubCD) neurons are thought to promote PGO waves and to be modulated by cholinergic afferents during REM sleep. We examined the differential effect of the cholinergic agonist carbachol (CAR) on excitatory and inhibitory postsynaptic currents (PSCs), and investigated the effects of CAR on SubCD neurons during the developmental decrease in REM sleep. DESIGN ...
متن کاملAssociation between abnormal REM sleep and negative symptoms in schizophrenia.
Although shortened rapid eye movement (REM) sleep latency, increased REM density, and decreased slow-wave sleep (SWS) are considered characteristic features of endogenous depression (Kupfer et al., 1978), several studies have reported similar findings in schizophrenic patients (reviewed in Zarcone et al., 1987). The latter observed that on the basis of REM abnormality, medication-free schizophr...
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Sleep disturbances of alcoholics while actively drinking and at the beginning of, and during, abstinence were frequently reported. Recently, Gillin et al. (1994) showed that a high "REM sleep pressure" at the time of admission to a 1-month inpatient alcohol treatment program predicted the relapse in nondepressed patients with primary alcoholism at 3 months following hospital discharge. We inves...
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Initial theories of rapid eye movement (REM) sleep generation posited that induction of the state required activation of the pontine subceruleus (SubC) by cholinergic inputs. Although the capacity of cholinergic neurotransmission to contribute to REM sleep generation has been established, the role of cholinergic inputs in the generation of REM sleep is ultimately undetermined as the critical te...
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Physiological measures of sensory gating are increasingly used to study biological factors associated with attentional dysfunction in psychiatric and neurologic patient populations. The present study was designed to assess sensory gating during rapid eye movement (REM) sleep in patients with schizophrenia, a population bearing a genetic load for gating impairment. Auditory event-related potenti...
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ژورنال
عنوان ژورنال: Schizophrenia Research
سال: 1992
ISSN: 0920-9964
DOI: 10.1016/0920-9964(92)90173-3